Key result
Caffeine-induced quantal Ca2+ release in smooth muscle cells is driven by SR Ca2+-ATPase activity.
Population
Isolated single smooth muscle cells
Design
Preclinical
Authors
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Does not change clinical calcium management; leaves open whether SR Ca2+-ATPase shapes human vascular smooth muscle responses.
The quantal release of calcium in response to caffeine in smooth muscle cells is largely driven by the SR Ca2+-ATPase returning released calcium back to the sarcoplasmic reticulum.
Steenbergen et al. (1996) studied Isolated single smooth muscle cells. Caffeine was evaluated on Calcium release from intracellular stores. Quantal release of Ca2+ in response to caffeine in smooth muscle cells is largely due to the activity of the SR Ca(2+)-ATPase, which returns a portion of the released Ca2+ back to the SR.
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