What question did this study set out to answer?

To quantify the loss of podocyte-specific proteins in diabetic nephropathy and evaluate urinary nephrin as a potential early biomarker in type 2 diabetes.

May 17, 2012PLoS ONEOpen Access

Dysregulated Nephrin in Diabetic Nephropathy of Type 2 Diabetes: A Cross Sectional Study

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Authors

BJBelinda JimAlbert Einstein College of Medicine MGMythili GhantaThe University of Texas Southwestern Medical Center AQAndi QipoBeth Israel Deaconess Medical Center

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Implication

Cross-sectional study uncovers urinary nephrin loss in normoalbuminuric type 2 diabetes, indicating nephrinuria may serve as an early biomarker of diabetic kidney disease.

Key Points

To quantify the loss of podocyte-specific proteins in diabetic nephropathy and evaluate urinary nephrin as a potential early biomarker in type 2 diabetes.
Quantified protein expression of synaptopodin, podocin, and nephrin in renal biopsies from 15 patients with type 2 diabetes and 12 controls.
Measured urinary nephrin levels via ELISA in 66 patients with type 2 diabetes stratified by albuminuria status alongside 10 healthy controls.
Renal biopsies demonstrated significant downregulation of synaptopodin (P < 0.0001), podocin (P = 0.0002), and nephrin (P < 0.0001) in diabetic nephropathy compared to controls.
Nephrinuria occurred in 100% of diabetic patients with micro- and macroalbuminuria and 54% with normoalbuminuria, correlating positively with albuminuria (rho = 0.89, P < 0.001) and negatively with eGFR (rho = -0.33, P = 0.005).

Cite This Study

Jim et al. (2012) studied this question.

synapsesocial.com/papers/6aa1095f8eabfe21f24f84bb https://doi.org/10.1371/journal.pone.0036041

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Implication

Cross-sectional study uncovers urinary nephrin loss in normoalbuminuric type 2 diabetes, indicating nephrinuria may serve as an early biomarker of diabetic kidney disease.

Dysregulated Nephrin in Diabetic Nephropathy of Type 2 Diabetes: A Cross Sectional Study

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Member takes

Implication

Key Points

Cite This Study

Dysregulated Nephrin in Diabetic Nephropathy of Type 2 Diabetes: A Cross Sectional Study

Discussion

Member takes

Implication

Key Points

Cite This Study

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