Key result
Review evaluates targeted antioxidant treatment for patients at risk of CV events with enhanced oxidative stress.
Why the study?
Should antioxidant status be considered to identify candidates for antioxidant treatment in patients at risk of cardiovascular disease?
Should antioxidant status be considered to identify candidates for antioxidant treatment in patients at risk of cardiovascular disease?
This review highlights the potential need to identify patients with enhanced oxidative stress as specific candidates for antioxidant therapy in cardiovascular disease trials.
Oxidative stress status should not yet guide antioxidant therapy; leaves open targeted trials in high-stress subgroups such as diabetes or hypertension.
The last decade has seen many trials with antioxidants in patients with cardiovascular disease, with equivocal results. One possible explanation for the disappointing findings is the lack of identification criteria of patients who are potential candidates for antioxidant treatment. Several studies have been carried out in patients at risk of cardiovascular disease, indicating that enhanced oxidative stress is associated with the presence of diabetes, hypercholesterolaemia, hypertension, and smoking. This review analyses the data reported so far to determine whether they clearly support the premise that patients at risk of cardiovascular events may be candidates for antioxidant treatment.
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Violi et al. (2004) conducted a review in Cardiovascular disease. Antioxidant treatment was evaluated. This review analyzes existing data to determine if patients at risk of cardiovascular events, who often have enhanced oxidative stress, are appropriate candidates for targeted antioxidant treatment.
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