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The quantitative histological changes in the seminiferous epithelium of the rat and mouse after whole-body irradiation have been compared. Dose levels of 100 and 300 r were used. In the rat there was no direct action on Type B spermatogonia, even at 300 r, although the LD50 for this cell stage in the mouse was 20–25 r. In both species there was a marked reduction in the number of Type A spermatogonia, but a proportion of these cells were radioresistant. The significance of these results is discussed.
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Partington et al. (1962) studied this question.
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