Key result
Donor-to-recipient RA anterior wall ratio, biopsy number, and dialysis linked to severe post-transplant TI.
Why the study?
Tricuspid insufficiency is the most common valvular complication after orthotopic heart transplantation and is linked to increased mortality, but the key risk factors and mechanisms driving its development and progression require identification.
What are the most important risk factors for the development and progression of functional tricuspid insufficiency after orthotopic heart transplantation?
Population
152 patients following heart transplantation with biatrial anastomosis
Comparison
Tricuspid insufficiency grade ≤2 vs grade >2
Design
Retrospective cohort study
Follow-up
>15 years
Authors
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Large single-center cohort identifies candidate risk factors for post-HTx TI; leaves open causal confirmation and need for prospective trials.
Observational (n=152)
No
What are the most important risk factors for the development and progression of functional tricuspid insufficiency after orthotopic heart transplantation?
Changes in tricuspid annulus geometry, number of biopsies, and dialysis are key risk factors for tricuspid insufficiency after heart transplantation, though severe TI did not impact long-term survival in patients with biatrial anastomosis.
Hajiyev et al. (2020) conducted an observational in Tricuspid insufficiency after heart transplantation (n=152). Risk factors (atrial geometry, biopsies, dialysis) vs. Absence of risk factors / lower severity of tricuspid insufficiency was evaluated on Development and progression of severe tricuspid insufficiency (grade >2). Donor to recipient right atrium anterior wall ratio (P<0.001), total biopsy number (P=0.003), and dialysis (P=0.026) were significantly associated with tricuspid insufficiency after transplantation.
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