Fate of Atrioventricular Valve Function of the Transplanted Heart
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Key result
Older donor age was independently associated with an increased risk of developing significant postoperative tricuspid regurgitation (HR 1.06) after heart transplantation.
Why the study?
Does anastomotic technique or donor age affect the long-term incidence of atrioventricular valve regurgitation in heart transplant recipients?
Population
201 adults who underwent orthotopic heart transplantation at a single center in South Korea. Key inclusion…
Comparison
Heart transplantation using bicaval anastomosis… vs Heart transplantation using standard anastomosis…
Design
Cohort
Follow-up
mean 89.9±54.3 months
Authors
Discussion
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Implication
Long-term post-transplant regurgitation data now quantified; leaves open whether findings should alter surveillance protocols.
Study Design
Type
Cohort (n=201)
Multicenter
No
Structured PICO
Does anastomotic technique or donor age affect the long-term incidence of atrioventricular valve regurgitation in heart transplant recipients?
P
Population
201 adult patients (mean age 42.8 years, 23.4% female) who underwent orthotopic heart transplantation, followed for a mean echocardiography duration of 89.9 months.
E
Exposure
Heart transplantation using bicaval anastomosis technique (n=148)
C
Comparator
Heart transplantation using standard anastomosis technique (n=53)
O
Outcome
Long-term incidence of moderate-to-severe tricuspid regurgitation (TR) and mitral regurgitation (MR) assessed quantitatively using transthoracic echocardiographysurrogate
Main Result
Hazard Ratio: 1.06 (95% CI 1.01–1.12)
p-value: p=0.012
Long-term atrioventricular valve function after heart transplantation is excellent regardless of anastomotic technique, though older donor age is an independent predictor of postoperative tricuspid regurgitation.
Limitations
- Retrospective study using observational data from a single center
- Missing baseline information, particularly donor's body weight
- Lack of data regarding antibody-mediated rejection
- Missing data regarding baseline information, particularly donor body weight
- Lack of data for antibody-mediated rejection
Cite This Study
Kim et al. (2014) conducted a cohort in Heart transplantation (n=201). Older donor age vs. Younger donor age was evaluated on Significant tricuspid regurgitation (moderate-to-severe) (HR 1.06, 95% CI 1.01-1.12, p=0.012). Older donor age was independently associated with an increased risk of developing significant postoperative tricuspid regurgitation (HR 1.06) after heart transplantation.
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