March 6, 2023Transplantation
Tricuspid Regurgitation After Heart Transplantation: The Cause or the Result of Graft Dysfunction?
Key result
Early moderate-severe tricuspid regurgitation after heart transplantation was significantly associated with postoperative ECMO use (78%; P<0.05) and rejection profile (P=0.02).
Why the study?
Tricuspid regurgitation is common after heart transplantation and adversely influences outcomes, but the causes of progression to moderate-severe TR in the first 2 years remain to be identified.
Population
163 patients who underwent heart transplantation over a 6-y period
Comparison
Progression or presence of moderate-severe TR vs nil-mild TR
Design
Retrospective, single-center study
Follow-up
1-2 y postoperatively
Authors
Discussion
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Member takes
Implication
TR post-transplant may mark graft dysfunction rather than drive it; leaves open causal trials targeting rejection over TR intervention.
Study Design
Type
Cohort (n=163)
Multicenter
No
Structured PICO
P
Population
163 patients who underwent heart transplantation over a 6-year period, evaluated for tricuspid regurgitation up to 2 years postoperatively.
O
Outcome
Presence and severity of tricuspid regurgitation (progression to moderate-severe TR in the first 2 years)surrogate
Tricuspid regurgitation after heart transplantation is more likely the result of underlying graft dysfunction rather than its cause.
Cite This Study
Bart et al. (2023) conducted a cohort in Tricuspid regurgitation after heart transplantation (n=163). Postoperative extracorporeal membrane oxygenation (ECMO) and rejection was evaluated on Causes of progression to moderate-severe tricuspid regurgitation. Early moderate-severe tricuspid regurgitation after heart transplantation was significantly associated with postoperative ECMO use (78%; P<0.05) and rejection profile (P=0.02).