PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
September 1, 2022British Journal of Cancer78 citationsOpen Access

Exosomal protein angiopoietin-like 4 mediated radioresistance of lung cancer by inhibiting ferroptosis under hypoxic microenvironment

View Full Paper
Ask AI
Bookmark
Share

Population

Human non-small cell lung cancer cell lines (A549 and H1299) and male nude mice xenograft models

Comparison

Hypoxia exposure, ANGPTL4 overexpression or… vs Normoxia, control vectors, and no irradiation

Design

Preclinical

Follow-up

up to 30 days for xenograft model

Key result

Hypoxia-induced ANGPTL4 promoted radioresistance in non-small cell lung cancer through intracellular and exosomal pathways by inhibiting GPX4-dependent ferroptosis.

Authors

YZYuhong ZhangXLXinglong LiuLZLiang Zeng

Discussion

Loading...

Member takes

Overview

May support ANGPTL4-ferroptosis targeting to overcome hypoxic radioresistance in NSCLC; leaves open human translation.

Structured PICO

P
Population
Preclinical study using in vitro human non-small cell lung cancer cell lines and in vivo mouse xenograft models to evaluate hypoxia-mediated radioresistance.
I
Intervention
Hypoxia exposure, ANGPTL4 overexpression or knockdown, and X-ray irradiation (single dose of 20 Gy for xenografts)
C
Comparator
Normoxia, control vectors, and no irradiation
O
Outcome
Radioresistance measured by colony survival and tumour growth delaysurrogate

Hypoxia-induced ANGPTL4 promotes radioresistance in non-small cell lung cancer by inhibiting ferroptosis, highlighting a potential therapeutic target to improve radiotherapy efficacy.

Cite This Study

Zhang et al. (2022) studied Non-small cell lung cancer. ANGPTL4 modulation and exosomal transfer vs. Control (normoxia or negative control vectors) was evaluated. Hypoxia-induced ANGPTL4 promoted radioresistance in non-small cell lung cancer through intracellular and exosomal pathways by inhibiting GPX4-dependent ferroptosis.

synapsesocial.com/papers/6aa11711afd97489ee8d3681https://doi.org/10.1038/s41416-022-01956-7
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Tumor cell-specific loss of GPX4 reprograms triacylglycerol metabolism to escape ferroptosis and impair antitumor immunity in NSCLC2025
  2. 2Involvement of ferroptosis‐defensive xCT/GPX4 axis in radioresistance and its impacts on prognosis in oral squamous cell carcinoma2024
  3. 3ANGPTL4 contributes to osimertinib resistance through NDRG1-associated extracellular matrix remodeling in EGFR-mutant NSCLC organoid models2026
  4. 4ANGPTL4 Regulates Lung Adenocarcinoma Pyroptosis and Apoptosis via NLRP3\ASC\Caspase 8 Signaling Pathway to Promote Resistance to Gefitinib2022 · 19 citations
  5. 5ANGPTL4 regulate glutamine metabolism and fatty acid oxidation in nonsmall cell lung cancer cells2022 · 52 citations