Distribution Ratios of Lipase-Catalyzed Reaction Products in Ionic Liquid Supercritical CO2 Systems: Resolution of 2-Octanol Enantiomers

This paper presents vapor−liquid equilibrium (VLE) data for systems containing high-pressure CO 2, an ionic liquid, and products of an enzymatic reaction between succinic anhydride and ( R, S )-2-octanol in the presence of a lipase. VLE experiments were used to calculate partition coefficients of reaction products between the ionic liquid-rich phase and the CO 2 -rich phase. Experiments of extraction with CO 2 from an ionic liquid of ( S )-2-octanol in conditions similar to those of the postreaction mixture were also carried out. The extraction at 11 MPa and 35 °C allows one to recover completely the unreacted enantiomer of 2-octanol with very high enantiomeric excess (98.42%).