What question did this study set out to answer?

To evaluate whether prolactin and other hormones modulate the production of gamma interferon in stimulated human peripheral blood mononuclear cells.

January 1, 1994Experimental Biology and Medicine

Enhanced Yields of Gamma Interferon in Prolactin Treated Human Peripheral Blood Mononuclear Cells

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Authors

TCThomas C. CesarioUniversity of California, Irvine SYSaber Yousefi GCG Carandang

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Implication

In vitro study demonstrates enhanced gamma interferon production in human blood mononuclear cells treated with prolactin, indicating an endocrine contribution to immune responses.

Key Points

To evaluate whether prolactin and other hormones modulate the production of gamma interferon in stimulated human peripheral blood mononuclear cells.
Cultured peripheral blood mononuclear cells (PBMC) obtained from 21 normal human donors across 30 separate experimental occasions.
Stimulated cells using varied inducers (lectins including PHA and Con A, anti-CD3 antibodies, ionophores, or IL-2) in the presence or absence of prolactin (≥10⁻⁸ M) and the tyrosine kinase inhibitor genistein.
Prolactin at concentrations of 10⁻⁸ M or greater dose-dependently doubled or further enhanced gamma interferon yield when induced by lectins (PHA and Con A), but not by anti-CD3 antibodies, ionophores, or IL-2.
Yield enhancement was observed in 27 of 30 test runs, and co-treatment with the tyrosine kinase inhibitor genistein completely abolished prolactin's stimulatory effect.

Cite This Study

Cesario et al. (1994) studied this question.

synapsesocial.com/papers/6aa119af71044162547d48fc https://doi.org/10.3181/00379727-205-43683

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Implication

In vitro study demonstrates enhanced gamma interferon production in human blood mononuclear cells treated with prolactin, indicating an endocrine contribution to immune responses.

Enhanced Yields of Gamma Interferon in Prolactin Treated Human Peripheral Blood Mononuclear Cells

Discussion

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Implication

Key Points

Cite This Study

Enhanced Yields of Gamma Interferon in Prolactin Treated Human Peripheral Blood Mononuclear Cells

Discussion

Member takes

Implication

Key Points

Cite This Study

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