Key result
Duodenal perfusion of oleic acid significantly increased superior mesenteric artery blood flow velocity and decreased resistance index compared to oleyl alcohol.
Why the study?
Does duodenal perfusion of oleic acid compared to oleyl alcohol increase superior mesenteric artery blood flow in healthy male volunteers?
Does duodenal perfusion of oleic acid compared to oleyl alcohol increase superior mesenteric artery blood flow in healthy male volunteers?
The carboxy group of oleic acid plays a key role in mediating postprandial increases in superior mesenteric artery blood flow.
Answers are grounded in this paper and cite their sources.
May implicate oleic acid's carboxy group in postprandial mesenteric hyperemia; leaves open relevance to clinical splanchnic vascular disorders.
BACKGROUND: The introduction of fat to the duodenum leads to an increase in mesenteric blood flow. The exact mechanism, however, is unknown. In this study we investigate the influence of the terminal carboxy group of the oleic acid molecule on superior mesenteric artery blood flow. METHODS: In six healthy male volunteers duplex ultrasound was used to evaluate the effects of duodenal perfusion of 48 mmol oleic acid and 48 mmol oleyl alcohol on superior mesenteric artery blood flow variables and diameter. RESULTS: The blood flow variables time-average velocity and maximal diastolic velocity increased significantly, and the resistance index decreased significantly during perfusion with oleic acid, but during oleyl alcohol perfusion no changes were found. No significant changes in vessel diameter were observed at any time. CONCLUSION: The carboxy group of the oleic acid molecule has an important role in the duodenum in mediating the postprandial increase in superior mesenteric artery blood flow.
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T C Andersen (1999) studied Healthy (n=6). Duodenal perfusion of oleic acid vs. 48 mmol oleyl alcohol was evaluated on Superior mesenteric artery blood flow variables and diameter. Duodenal perfusion of oleic acid significantly increased superior mesenteric artery blood flow velocity and decreased resistance index compared to oleyl alcohol.
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