Key result
MSA and desmin identify ~100% of rhabdomyosarcomas but lack sensitivity for formalin-fixed leiomyosarcomas.
Population
576 samples of normal, reactive, and neoplastic tissues
Design
Other
Authors
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Supports rhabdomyosarcoma diagnosis in pathology; leaves open optimal markers for formalin-fixed leiomyosarcomas.
Cross-Sectional (n=576)
Both MSA and desmin are sensitive and specific markers for rhabdomyosarcoma, though MSA stains a broader range of cell types including pericytes and myoepithelial cells.
Rangdaeng et al. (1991) conducted a cross-sectional in Normal, reactive, and neoplastic tissues (n=576). Muscle-specific actin (MSA) and desmin staining was evaluated on Staining patterns for MSA and desmin. Muscle-specific actin and desmin are sensitive and specific markers for rhabdomyosarcoma (found in 34 of 34 cases), but have low sensitivity for formalin-fixed leiomyosarcomas.
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