Key result
Group 3 PH in females linked to ~3% lower RVFAC compared to PAH.
Why the study?
Group 3 pulmonary hypertension patients have disproportionate right ventricular dysfunction compared to pulmonary arterial hypertension patients, but the cause and the combined effects of PH type and sex on RV function are unexplored.
Does Group 3 pulmonary hypertension etiology compared to PAH etiology worsen right ventricular dysfunction in females?
Cohort (n=450)
No
Does Group 3 pulmonary hypertension etiology compared to PAH etiology worsen right ventricular dysfunction in females?
Answers are grounded in this paper and cite their sources.
Females with Group 3 pulmonary hypertension exhibit exaggerated right ventricular dysfunction compared to females with pulmonary arterial hypertension, suggesting chronic lung disease and aging exacerbate RVD in this population.
Group 3 pulmonary hypertension (PH) patients have disproportionate right ventricular dysfunction (RVD) as compared to pulmonary arterial hypertension (PAH) patients, but the cause of the divergent RV phenotypes is unknown. One potential mechanism may be biological sex as females have better RV function than males. However, the combined effects of PH type and sex on RV function are unexplored. Therefore, we evaluated how sex and PH etiology modulated RVD in a single-center cohort study. Male sex was not associated with significant differences in RV function when comparing PH etiologies. However, female Group 3 patients had more pronounced RVD than female PAH patients. In particular, Group 3 females had marked reduction in RV function when pulmonary vascular resistance was matched. Group 3 females were older than PAH females, but the exaggerated RVD was still observed in postmenopausal (age≥55) Group 3 females. This suggests lung disease exacerbates RVD in Group 3 females.
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Prisco et al. (2021) conducted a cohort in Pulmonary hypertension (n=450). Group 3 pulmonary hypertension vs. Group 1 pulmonary arterial hypertension was evaluated on Right ventricular fractional area change (RVFAC) in females (p=0.049). Female patients with Group 3 pulmonary hypertension had significantly lower right ventricular fractional area change compared to female patients with pulmonary arterial hypertension (32% vs 35%, p=0.049).
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