Key result
Genetic and environmental factors like obesity and diet drive metabolic syndrome and insulin resistance.
This review provides a comprehensive overview of the genetic, environmental, and molecular factors contributing to the development of insulin resistance and metabolic syndrome.
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Pathophysiology of metabolic syndrome remains incompletely defined; leaves open mechanistic research before targeted interventions.
Metabolic syndrome and insulin resistance has been the subject of much debate over the last two decades. Its pathophysiologycal basis, however, still remains to be clearly understood. Both genetic and environmental factors have been implicated in its pathogenesis. Mutation of genes encoding signal transduction molecules of insulin and acquired factors like aging, diets, physical activity, obesity and related molecular changes, dyslipidemia, hypertension and smoking were proposed by many groups. This review examined both acquired and genetic factors and discussed model of hormone-receptor-postreceptor interactions to explore the molecular basis of insulin resistance. DOI: http://dx.doi.org/10.3329/bjmb.v4i2.13773 Bangladesh J Med Biochem 2011; 4(2): 26-31
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Al-Mahmood et al. (2013) conducted a review in Metabolic Syndrome and Insulin resistance. Metabolic syndrome and insulin resistance are driven by a combination of genetic factors and acquired environmental influences such as aging, diet, physical inactivity, obesity, and hypertension.
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