Key result
First-degree relatives of type 2 diabetic patients had 45% lower adiponectin mRNA expression in subcutaneous adipose tissue compared with matched controls (P<0.01).
Why the study?
Does adiponectin expression and its response to hyperinsulinemia differ in healthy first-degree relatives of type 2 diabetic patients compared to matched controls?
Population
22 healthy first-degree relatives to type 2 diabetic patients and 13 matched control subjects
Comparison
Hyperinsulinemic euglycemic clamp and… vs Matched control subjects
Design
Case-control
Authors
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May flag preclinical adipose dysfunction in T2D families; leaves open whether adiponectin expression predicts or modifies diabetes risk.
Observational (n=35)
Does adiponectin expression and its response to hyperinsulinemia differ in healthy first-degree relatives of type 2 diabetic patients compared to matched controls?
Effect estimate: 45% lower
p-value: p=<0.01
Healthy first-degree relatives of type 2 diabetic patients exhibit reduced adiponectin mRNA expression in adipose tissue despite normal circulating levels, indicating early dysregulation of adiponectin gene expression.
Lihn et al. (2003) conducted an observational in First-degree relatives of type 2 diabetic patients (n=35). First-degree relative of type 2 diabetic patient vs. Matched control subjects was evaluated on Adiponectin mRNA expression in subcutaneous adipose tissue (45% lower, p=<0.01). First-degree relatives of type 2 diabetic patients had 45% lower adiponectin mRNA expression in subcutaneous adipose tissue compared with matched controls (P<0.01).
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