Key result
Phyllanthus emblica L. extract at 400 mg/kg BW reduced CK-MB levels and improved heart tissue histopathology in male Wistar rats with doxorubicin-induced cardiotoxicity.
Why the study?
Long-term use of doxorubicin causes cardiotoxicity via reactive oxygen species, prompting evaluation of natural antioxidant sources with in vivo cardioprotective capabilities.
Does Phyllanthus emblica L. extract prevent doxorubicin-induced cardiotoxicity in male Wistar rats?
Does Phyllanthus emblica L. extract prevent doxorubicin-induced cardiotoxicity in male Wistar rats?
Phyllanthus emblica L. extract at 400 mg/kg BW demonstrates potential cardioprotective effects against doxorubicin-induced cardiotoxicity in a rat model.
Supports further preclinical research on Phyllanthus emblica; leaves open translation to human doxorubicin cardiotoxicity prevention.
Doxorubicin as a chemotherapy agent is most widely used in cancer treatment. Long-term use at a predetermined dose has a side effect, namely cardiotoxicity. Doxorubicin-induced cardiotoxicity is considered to be caused by reactive oxygen species (ROS), which is also characterized by increasing CK-MB enzyme levels in the blood. To reduce the impact of doxorubin-induced toxicity, a study was conducted on natural antioxidant sources with cardioprotective capabilities in vivo. Phyllanthus emblica L. fruit was used as a sample for a natural source of antioxidants extracted using ethanol. Then performed a phytochemical screening of secondary metabolites contained in it. This extract was administered orally in various doses to the experimental animal Wistar rats and the induced doxorubicin to these animals. The CK-MB enzyme levels were measured, and the heart organ histopathology test was performed. The results of this study indicate that P. emblica L. fruit extract contains alkaloids, tannins, flavonoids, terpenoids, phenolics, and triterpenoids compounds. Extract treatment at a 400 mg/kg BW dose showed the best reduction in CK-MB levels with great improvements in regular arrangement and shape of myocardial muscle cells of cardiac tissue. The sample extract at a 400 mg/kg BW dose showed remarkably decreasing of CK-MB great improvements of heart tissue on doxorubicin-induced cardiotoxicity. This study showed the potential protective effect of P. emblica L. against doxorubicin-induced cardiotoxicity.
No takes yet. Share an insight, caveat, or question.
MELINDA et al. (2021) studied Doxorubicin-induced cardiotoxicity. Phyllanthus emblica L. extract was evaluated on CK-MB enzyme levels and heart organ histopathology. Phyllanthus emblica L. extract at 400 mg/kg BW reduced CK-MB levels and improved heart tissue histopathology in male Wistar rats with doxorubicin-induced cardiotoxicity.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: