Key result
Vitamin E pretreatment significantly prevented PR, QT, and ST segment changes and decreased CPK-MB and LDH levels caused by doxorubicin-induced myocardial damage in rats.
Why the study?
Does vitamin E pretreatment prevent doxorubicin-induced acute cardiotoxicity in rats?
Population
18 Wistar male rats (age 60 - 100 days, weighing 175 - 260 g)
Comparison
Pretreatment with a high dose of vitamin E for 2… vs Doxorubicin treatment alone and untreated controls
Design
Preclinical
Follow-up
7 days after the last dose of doxorubicin
Authors
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May protect against doxorubicin cardiotoxicity in rats; hypothesis-generating and requires clinical trials before any practice change.
Does vitamin E pretreatment prevent doxorubicin-induced acute cardiotoxicity in rats?
Absolute Event Rate: 0.057% vs 0.07%
p-value: p=0.0024
Vitamin E pretreatment protects against doxorubicin-induced electrocardiographic and biochemical myocardial damage in a rat model.
Puri et al. (2005) studied Doxorubicin-induced acute cardiotoxicity (n=18). Vitamin E vs. Doxorubicin alone and healthy controls was evaluated on PR interval (seconds) (p=0.0024). Vitamin E pretreatment significantly prevented PR, QT, and ST segment changes and decreased CPK-MB and LDH levels caused by doxorubicin-induced myocardial damage in rats.
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