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All articles of this category Intramolecular aldol reactions of cis-N -acyloxazolidines 6a,b gave protected α-substituted pyroglutamates. The observed stereocontrol arises as a result of the chiral memory of the oxazolidine template, and regioselective enolate formation prior to ring closure. The major products, 10 and 12 , have the correct relative stereochemistry for the oxazolomycin group of antitumour antibiotics. pyroglutamate - intramolecular - cyclization - aldol - oxazolomycin
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Andrews et al. (1996) studied this question.
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