Total Synthesis of the Squalene Synthase Inhibitor Zaragozic Acid C

All articles of this category The total synthesis of zaragozic acid C has been achieved by a convergent strategy, wherein the key feature of the construction of 2,8-dioxabicyclo[3.2.1]octane core structure is a simultaneous creation of the C4 and C5 quaternary carbon centers by Sn(OTf) 2 -promoted aldol coupling reaction between α-keto ester and silyl ketene thioacetal derived from L- and D-tartaric acids, respectively. zaragozic acid C - squalene synthase inhibitor - Sn(OTf) 2 -promoted aldol coupling reaction - silyl ketene thioacetal - α-keto ester