Key result
Obesity is associated with inflammation, neurodegeneration, and immune function alterations, driven by leukocyte infiltration in adipose tissue and pro-inflammatory cytokine release.
This review emphasizes the complex interplay between obesity, systemic inflammation, and neurological alterations such as major depression.
Inflammation, neurodegeneration, imbalance of neurotransmitter systems, oxidative stress and depression are all risk factors for obesity. There is evidence regarding the cross-talk between adipose tissue and the immune system and obese patients may show an alteration of immune functions with major depression, including immune suppression with reduced T-cell and macrophage activity. Obesity is mediated by inflammatory cells such as lymphocytes, macrophages and mast cells which release pro-inflammatory cytokines and chemokines. Obesity-induced leukocyte infiltrations in adipose tissue cause cytokine/chemokine release and inflammation. Here, we report the relationship between obesity, neurological alterations and inflammation.
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Spinas et al. (2014) conducted a review in Obesity. Obesity was evaluated. Obesity is associated with inflammation, neurodegeneration, and immune function alterations, driven by leukocyte infiltration in adipose tissue and pro-inflammatory cytokine release.
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