Key result
CT premedication carries a ~13% risk of adverse reactions in hospitalized children, driven by high doses.
Why the study?
What are the rates and risk factors for adverse reactions to premedication for CT head scans in hospitalized children?
Population
106 hospitalized children undergoing computed tomographic head scans monitored by an intensive drug…
Design
Cohort
Authors
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Caution advised for premedication in infants and with high doses or polypharmacy; leaves open safer regimens for prospective trials.
Observational (n=106)
What are the rates and risk factors for adverse reactions to premedication for CT head scans in hospitalized children?
Relative Risk: 5.2
Premedication for CT scans in hospitalized children carries a 13% risk of adverse reactions, including life-threatening cardiorespiratory depression, particularly in infants under 3 months and those receiving high doses or multiple medications.
Allen A. Mitchell (1982) conducted an observational in Hospitalized children requiring premedication for CT head scans (n=106). Premedication for CT head scans was evaluated on Adverse reactions (RR 5.2). Premedication for CT head scans in hospitalized children caused adverse reactions in 13% of patients, with risks elevated by high doses (RR 5.2) and receiving four or more medications (RR 3.7).
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