September 21, 2017PLoS ONEOpen Access

Intercalated disc in failing hearts from patients with dilated cardiomyopathy: Its role in the depressed left ventricular function

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Dilated cardiomyopathy (n=35). Intervention: Dilated cardiomyopathy vs. Non-diseased control donors. Primary outcome: Correlation of GJA3 gene expression with left ventricular ejection fraction (r = 0.741, p=0.004).

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Key result

Downregulated intercalated disc genes in DCM strongly correlate with reduced LVEF.

r = 0.741
P=0.004
n=35

Authors

AOAna OrtegaCentro de Investigación en Red en Enfermedades Cardiovasculares ETEstefanía TarazónHeart Failure & Transplant CGCarolina Gil‐CayuelaLeitat Technological Center

Discussion

Member takes

Implication

Dysregulated ID adhesion transcripts associate with LV decay in DCM; leaves open whether these changes drive progression or offer therapeutic targets.

Study Design

Type

Observational (n=35)

Multicenter

PICO

Population

35 left ventricular tissue samples from patients with dilated cardiomyopathy undergoing heart transplantation and non-diseased control donors.

Exposure / Comparator

Dilated cardiomyopathy vs Non-diseased control donors

Primary Outcome

Correlation of GJA3 gene expression with left ventricular ejection fraction — r = 0.741, p=0.004

Main Result

Effect estimate: r = 0.741

p-value: p=0.004

Limitations

High variability in disease etiology among end-stage failing human hearts
Patients were under heavy medical treatment

Cite This Study

Ortega et al. (2017) conducted an observational in Dilated cardiomyopathy (n=35). Dilated cardiomyopathy vs. Non-diseased control donors was evaluated on Correlation of GJA3 gene expression with left ventricular ejection fraction (r = 0.741, p=0.004). Dilated cardiomyopathy is associated with significant downregulation of intercalated disc genes GJA3, DSP, and CTNNA3, which strongly correlates with reduced left ventricular ejection fraction.

synapsesocial.com/papers/6aa163bae90d587b1c3d4aa8 https://doi.org/10.1371/journal.pone.0185062

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Implication

Dysregulated ID adhesion transcripts associate with LV decay in DCM; leaves open whether these changes drive progression or offer therapeutic targets.

Intercalated disc in failing hearts from patients with dilated cardiomyopathy: Its role in the depressed left ventricular function

Discussion

Member takes

Implication

Study Design

PICO

Main Result

Limitations

Cite This Study

Intercalated disc in failing hearts from patients with dilated cardiomyopathy: Its role in the depressed left ventricular function

Discussion

Member takes

Implication

Study Design

PICO

Main Result

Limitations

Cite This Study

Also Consider

Also Consider