July 26, 2017PLoS ONEOpen Access

Symptomatic carotid plaques show a ~43% higher median lipid percentage than asymptomatic plaques.

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Carotid artery disease (n=50). Intervention: Symptomatic carotid plaque vs. Asymptomatic carotid plaque. Primary outcome: Plaque lipid percentage in slice with maximal lipid content (p=0.013).

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Why the study?

Does magnetic resonance T2 mapping of carotid plaque lipid content and distribution differentiate symptomatic from asymptomatic patients with carotid artery disease?

Population

50 adult patients scheduled for carotid endarterectomy with recently symptomatic or asymptomatic carotid…

Comparison

Magnetic resonance T2 mapping using DANTE-MESE… vs Asymptomatic patients vs. symptomatic patients

Design

Cross-sectional, Lipid area and number of lipid particles were segmented and…

Key result

Symptomatic carotid plaques had a significantly higher median lipid percentage (30.8%) compared to asymptomatic plaques (21.5%) in patients undergoing carotid endarterectomy.

Authors

MAMohammad Alkhalil LBLuca Biasiolli JCJoshua T. Chai

Discussion

Member takes

Overview

Plaque lipid on T2-mapping was associated with symptoms independent of stenosis; leaves open its utility for stratifying asymptomatic carotid disease.

Study Design

Type

Observational (n=50)

Blinding

Single-blind

Multicenter

Structured PICO

Does magnetic resonance T2 mapping of carotid plaque lipid content and distribution differentiate symptomatic from asymptomatic patients with carotid artery disease?

Population

50 adult patients with 50-99% carotid stenosis scheduled for carotid endarterectomy underwent preoperative MRI T2 mapping to compare plaque lipid content between symptomatic and asymptomatic arteries.

Exposure

Magnetic resonance T2 mapping using DANTE-MESE sequence to quantify carotid plaque lipid content and distribution (Lipid Aggregation Index [LAI] and Largest Lipid Deposit [LLD%])

Comparator

Asymptomatic patients vs. symptomatic patients

Outcome

Plaque lipid percentage and lipid distribution (LLD% and LAI) in symptomatic vs. asymptomatic patientssurrogate

Main Result

Absolute Event Rate: 30.8% vs 21.5%

p-value: p=0.013

Non-invasive MRI T2 mapping demonstrates that carotid plaque lipid content and coalesced distribution are significantly higher in symptomatic patients, independent of the degree of luminal stenosis.

Limitations

Sensitivity to motion artefacts of the DANTE-MESE sequence leading to a 29.5% scan rejection rate
Lipid aggregation index (LAI) is not calculable in slices with a single lipid deposit
Sensitivity to motion artefacts of the DANTE-MESE sequence resulting in a 29.5% scan rejection rate

Cite This Study

Alkhalil et al. (2017) conducted an observational in Carotid artery disease (n=50). Symptomatic carotid plaque vs. Asymptomatic carotid plaque was evaluated on Plaque lipid percentage in slice with maximal lipid content (p=0.013). Symptomatic carotid plaques had a significantly higher median lipid percentage (30.8%) compared to asymptomatic plaques (21.5%) in patients undergoing carotid endarterectomy.

synapsesocial.com/papers/6aa16ae9dc6fbdec443d4df6 https://doi.org/10.1371/journal.pone.0181668

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July 26, 2017PLoS ONEOpen Access

Symptomatic carotid plaques show a ~43% higher median lipid percentage than asymptomatic plaques.

View Full Paper

Ask AI

Bookmark

Why the study?

Does magnetic resonance T2 mapping of carotid plaque lipid content and distribution differentiate symptomatic from asymptomatic patients with carotid artery disease?

Population

50 adult patients scheduled for carotid endarterectomy with recently symptomatic or asymptomatic carotid…

Comparison

Magnetic resonance T2 mapping using DANTE-MESE… vs Asymptomatic patients vs. symptomatic patients

Design

Cross-sectional, Lipid area and number of lipid particles were segmented and…

Key result

Symptomatic carotid plaques had a significantly higher median lipid percentage (30.8%) compared to asymptomatic plaques (21.5%) in patients undergoing carotid endarterectomy.

Authors

MAMohammad Alkhalil LBLuca Biasiolli JCJoshua T. Chai

Discussion

Member takes

Overview

Plaque lipid on T2-mapping was associated with symptoms independent of stenosis; leaves open its utility for stratifying asymptomatic carotid disease.

Study Design

Type

Observational (n=50)

Blinding

Single-blind

Multicenter

Structured PICO

Does magnetic resonance T2 mapping of carotid plaque lipid content and distribution differentiate symptomatic from asymptomatic patients with carotid artery disease?

Population

Exposure

Magnetic resonance T2 mapping using DANTE-MESE sequence to quantify carotid plaque lipid content and distribution (Lipid Aggregation Index [LAI] and Largest Lipid Deposit [LLD%])

Comparator

Asymptomatic patients vs. symptomatic patients

Outcome

Plaque lipid percentage and lipid distribution (LLD% and LAI) in symptomatic vs. asymptomatic patientssurrogate

Main Result

Absolute Event Rate: 30.8% vs 21.5%

p-value: p=0.013

Non-invasive MRI T2 mapping demonstrates that carotid plaque lipid content and coalesced distribution are significantly higher in symptomatic patients, independent of the degree of luminal stenosis.

Limitations

Sensitivity to motion artefacts of the DANTE-MESE sequence leading to a 29.5% scan rejection rate
Lipid aggregation index (LAI) is not calculable in slices with a single lipid deposit
Sensitivity to motion artefacts of the DANTE-MESE sequence resulting in a 29.5% scan rejection rate

Cite This Study

synapsesocial.com/papers/6aa16ae9dc6fbdec443d4df6 https://doi.org/10.1371/journal.pone.0181668

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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