Key result
The ratio of O2 consumption rate to O2 transmissibility was higher near the endothelium than in the outer wall, indicating O2 supply from vasa vasorum is essential to prevent medial wall hypoxia.
Population
Rabbit aortic tissue in vitro (n=9) and various dog vessels in vivo
Design
Preclinical
Authors
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Hypothesis-generating for vasa vasorum in arterial oxygenation; requires human validation before any clinical consideration.
The study demonstrates that arterial wall oxygen consumption is spatially heterogeneous, being higher near the endothelium, and suggests vasa vasorum oxygen supply is essential to prevent medial wall hypoxia.
Buerk et al. (1982) studied this question. O2 tension profile measurement was evaluated on Ratio of O2 consumption rate (Q) to O2 transmissibility (Dk). The ratio of O2 consumption rate to O2 transmissibility was higher near the endothelium than in the outer wall, indicating O2 supply from vasa vasorum is essential to prevent medial wall hypoxia.
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