Key result
Genetic factors explained a moderate proportion of carotid distensibility variability, with age- and sex-adjusted heritability of 25% for strain, 17% for distensibility, and 20% for stiffness.
Observational (n=693)
Genetic factors explain a moderate proportion (17-25%) of the variability in carotid artery distensibility among high-risk Caribbean Hispanics, independent of age and sex.
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Moderate heritability supports targeted genetic studies in high-risk families; should not yet alter clinical vascular assessment.
Juo et al. (2005) conducted an observational in Cardiovascular risk (n=693). Genetic factors was evaluated on Age- and sex-adjusted heritability of carotid distensibility metrics (strain, stiffness, distensibility, and elastic modulus). Genetic factors explained a moderate proportion of carotid distensibility variability, with age- and sex-adjusted heritability of 25% for strain, 17% for distensibility, and 20% for stiffness.