Heritability of Carotid Artery Structure and Function
Key result
Genetic factors explained a moderate proportion of the variability in carotid artery structure and function, with significant heritabilities for diastolic diameter (h2<0.44) and IMT (h2<0.21).
Population
Approximately 950 men and women, aged ≥18 years, in 32 extended families of American Indians
Design
Cross-sectional
Authors
Discussion
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Implication
Moderate heritability of carotid traits in American Indians; leaves open targeted gene discovery before any clinical translation.
Study Design
Type
Observational (n=950)
Structured PICO
P
Population
950 American Indian men and women aged ≥18 years from 32 extended families, evaluated for genetic contributions to carotid artery structure and function.
O
Outcome
Heritability of carotid artery structure and function phenotypes (common carotid artery diastolic diameter, intimal-medial wall thickness, vascular mass, arterial stiffness, and augmentation index)surrogate
Main Result
Effect estimate: h2 <0.44
Additive genetic effects explain a moderate proportion of the variability in carotid artery structure and function in American Indians.
Cite This Study
North et al. (2002) conducted an observational in Carotid artery structure and function (n=950). Genetic factors was evaluated on Heritability of carotid artery structure and function phenotypes (h2 <0.44). Genetic factors explained a moderate proportion of the variability in carotid artery structure and function, with significant heritabilities for diastolic diameter (h2<0.44) and IMT (h2<0.21).