Key result
Short-term exercise reduced infarct size in male rats after 1 day (27% vs 37%, P<0.05) and in female rats after 5 days (13% vs 25%, P<0.05) of treadmill running.
Why the study?
Does short-term exercise reduce infarct size following myocardial ischaemia-reperfusion injury in male and female rats?
Population
Male and female rats
Comparison
Short-term exercise vs Sedentary (0 days of treadmill running)
Design
Preclinical
Authors
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Animal data preclude practice change; leaves open sex-specific exercise preconditioning against ischaemia-reperfusion injury.
Does short-term exercise reduce infarct size following myocardial ischaemia-reperfusion injury in male and female rats?
p-value: p=<0.05
Short-term exercise induces sex-dependent cardioprotection against ischaemia-reperfusion injury in rats, potentially mediated by increased expression of cardiac sarcolemmal K(ATP) channels.
Brown et al. (2005) studied Myocardial ischaemia-reperfusion injury (n=46). Short-term exercise (treadmill running) vs. Sedentary (0 days) was evaluated on Infarct size (percentage of the zone at risk) (p=<0.05). Short-term exercise reduced infarct size in male rats after 1 day (27% vs 37%, P<0.05) and in female rats after 5 days (13% vs 25%, P<0.05) of treadmill running.
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