Why the study?
Does endurance exercise training reduce infarct size and preserve coronary flow after ischemia-reperfusion in female Sprague-Dawley rats?
Population
Female Sprague-Dawley rats
Comparison
Endurance exercise training for 20 weeks vs Sedentary control group
Design
Preclinical, randomly assigned
Follow-up
20 weeks
Authors
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Supports infarct sparing by training in rats; hypothesis-generating and not ready for clinical translation.
Does endurance exercise training reduce infarct size and preserve coronary flow after ischemia-reperfusion in female Sprague-Dawley rats?
Long-term exercise training in a rat model leads to infarct sparing and better maintenance of coronary flow and mechanical function after ischemia-reperfusion.
Brown et al. (2003) studied this question.
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