What does this research mean for the field?

Chronic exercise reduces myocardial infarct size by 30% following coronary artery occlusion in rats, an effect that occurs without hypertrophy and is likely mediated by increased myocardial vascularity. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To investigate the effects of chronic exercise on myocardial infarct size and vascularity in rats after coronary artery occlusion.

May 1, 1978Circulation

Exercise-induced reduction in myocardial infarct size after coronary artery occlusion in the rat.

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Why the study?

Does chronic exercise reduce myocardial infarct size after coronary artery occlusion in rats?

Population

Rats (n=60 total; 8 for histologic capillary assessment, 52 for infarct size assessment)

Comparison

Chronic exercise vs Sedentary controls

Design

Preclinical

Follow-up

48 hours post-occlusion

Authors

CMChristopher L. McElroyUniversity of North Texas SGSally A. GissenCedars-Sinai Medical Center MFMichael C. FishbeinElectrophysiology

Discussion

Member takes

Implication

No immediate clinical implications; leaves open translation of exercise preconditioning to human infarction.

Key Points

To investigate the effects of chronic exercise on myocardial infarct size and vascularity in rats after coronary artery occlusion.
Rats were forced to swim 1 hr/day, 5 days/week for 5 weeks.
Myocardial capillary bed was perfused with carbon black, and histologic sections were examined for capillary/fiber ratios and fiber diameter.
After exercise, some rats underwent left coronary artery occlusion, and myocardial infarct size was measured.
Infarct size in E rats was 21.5 +/- 1.9% of the left ventricle compared to 31.3 +/- 2.6% in C rats (P < 0.005), representing a 30% reduction.
Capillary/fiber ratio increased by 30% in E rats (0.87 +/- 0.06) compared to C rats (0.67 +/- 0.04, P < 0.05).
No differences in ventricular weight or myocardial fiber diameter were observed between the groups.

Structured PICO

Does chronic exercise reduce myocardial infarct size after coronary artery occlusion in rats?

Population

Rats (n=60 total; 8 for histologic capillary assessment, 52 for infarct size assessment)

Intervention

Chronic exercise (forced swimming 1 hour/day, 5 days/week for 5 weeks)

Comparator

Sedentary controls

Outcome

Myocardial infarct size measured by planimetry of histologic sections of serial slices of left ventricle 48 hours after left coronary artery occlusionsurrogate

Chronic exercise reduces myocardial infarct size following coronary artery occlusion in a rat model, potentially due to increased myocardial vascularity.

Cite This Study

McElroy et al. (1978) studied this question.

synapsesocial.com/papers/6a169d272fcf950e0005100c https://doi.org/10.1161/01.cir.57.5.958

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Exercise-induced reduction in myocardial infarct size after coronary artery occlusion in the rat.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Exercise-induced reduction in myocardial infarct size after coronary artery occlusion in the rat.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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