Key result
Baseline troponin I shows no significant correlation with post-PCI coronary flow in STEMI patients.
Why the study?
While troponin I correlates with the scale of myocardial infarction area, its relationship with coronary flow and revascularization success after primary PCI in STEMI patients had not been reported.
Does high sensitivity troponin I level at presentation correlate with coronary flow (cTFC) after primary PCI in STEMI patients?
Observational (n=96)
No
Does high sensitivity troponin I level at presentation correlate with coronary flow (cTFC) after primary PCI in STEMI patients?
Effect estimate: r = -0.092
p-value: p=0.371
High sensitivity troponin I levels at presentation do not significantly correlate with post-PCI coronary flow (measured by cTFC) in STEMI patients.
May link hs-troponin I to PPCI success in STEMI; leaves open validation before any clinical role.
Objective: There were studies reported about the correlation between troponin I with scale of myocardial infarction (MI) area. However, the effect of revascularization into the coronary flow has not been reported. We aim to determine the correlation between high sensitivity troponin I and the successfulness of revascularization primary percutaneous coronary intervention (PPCI) in ST-elevation MI (STEMI) patients. The successfulness of revascularization was assessed by calculating Corrected thrombolysis in MI frame count (CTFC). Methods: This is a retrospective analysis including all consecutive patients undergoing PPCI over 1-year period from December 2018 to 2019 at the Integrated Heart Service Installation Dr. M. Djamil Padang Hospital, West Sumatra. Exclusion criteria included patients with incomplete medical record data, incomplete coronary angiography data, prior MI, and prior PCI and coronary artery bypass graft. Patients were put into two groups with normal (CTFC <30) and high (CTFC ≥30) to define the baseline characteristics. Results: A retrospective analysis was performed of patients undergoing primary PCI. Ninety-six patients underwent PPCI between December 2018 and 2019 were enrolled. For the baseline characteristic, patient was divided into two groups with normal CTFC (<30) and high (CTFC ≥30). There was negative weak correlation between troponin I level and CTFC with Spearman’s correlation value was 0.371 and correlation coefficient −0.092. Conclusion: Troponin I level at first presentation before revascularization did not have a significant correlation with coronary flow result after revascularization in STEMI patients.
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Syafri et al. (2020) conducted an observational in ST-elevation myocardial infarction (STEMI) (n=96). High sensitivity troponin I level was evaluated on Correlation between troponin I level and Corrected TIMI frame count (CTFC) (r = -0.092, p=0.371). Troponin I level at first presentation before revascularization had a weak, non-significant negative correlation (r = -0.092, p=0.371) with coronary flow result (CTFC) after primary percutaneous coronary intervention in STEMI patients.
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