Key result
Reduced miR-203 in aldosterone-producing adenomas increases aldosterone production and tumorigenesis via Wnt5a/β-catenin activation.
Population
Primary aldosterone-producing adenoma cells, human adrenocortical cell line HAC15, C57BL/6 mice, and human…
Comparison
Upregulation or downregulation of miR-203 via… vs Peritumor adrenal samples; control conditions…
Design
Preclinical
Authors
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Lower miR-203 in APAs links to aldosterone excess and tumor size; leaves open prognostic or therapeutic roles pending validation.
Attenuated miR-203 expression in aldosterone-producing adenomas drives aldosterone hypersecretion and cell proliferation via the Wnt5a/β-catenin pathway, suggesting a potential therapeutic target and biomarker for secondary hypertension.
Peng et al. (2018) studied Aldosterone-producing adenomas. miR-203 expression modulation was evaluated on Aldosterone production and cell proliferation. Attenuated miR-203 expression in aldosterone-producing adenomas increases aldosterone production and tumorigenesis by activating the Wnt5a/β-catenin pathway.
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