Key result
Surgically repaired tetralogy of Fallot shows ~58% lower pulmonary annulus isovolumic acceleration versus healthy controls.
Why the study?
Assessment of RV function is important in surgically corrected TOF, but quantitative assessment remains challenging mainly because of complex RV geometry.
Does isovolumic acceleration of the pulmonary annulus (PA-IVA) provide a useful index to assess right ventricular outflow tract function in patients with surgically repaired tetralogy of Fallot?
Observational (n=79)
Does isovolumic acceleration of the pulmonary annulus (PA-IVA) provide a useful index to assess right ventricular outflow tract function in patients with surgically repaired tetralogy of Fallot?
Absolute Event Rate: 1% vs 2.4%
p-value: p=<0.05
Isovolumic acceleration of the pulmonary annulus is a useful, load-independent echocardiographic parameter for assessing right ventricular outflow tract systolic function in patients with surgically repaired tetralogy of Fallot.
PA-IVA may aid RVOT assessment in repaired TOF; leaves open validation against outcomes or CMR before routine use.
Assessment of right ventricular (RV) function is quite important in patients with surgically corrected tetralogy of Fallot (TOF). However, quantitative assessment of RV function remains challenging, mainly because of the complex RV geometry. This prospective study investigated isovolumic acceleration (IVA), a parameter of myocardial systolic function not influenced by either preload or afterload, using tissue Doppler imaging. We evaluated IVA measured on pulmonary annulus (PA-IVA) and tricuspid annulus (TA-IVA), because we considered that PA-IVA and TA-IVA correspond with systolic function of the RV outflow tract (RVOT) and RV basal function, respectively. Thirty-nine patients with surgically repaired TOF (TOF group) and 40 age-matched healthy children (control group) were enrolled in this study. No significant difference was seen between TA-IVA (2.5 ± 0.8 m/s2) and PA-IVA (2.4 ± 0.8 m/s2) in the control group. In the TOF group, PA-IVA (1.0 ± 0.5 m/s2) was significantly lower than TA-IVA (1.3 ± 0.6 m/s2, p < 0.05). Both TA-IVA and PA-IVA were significantly lower in the TOF group than in the control group (p < 0.05 each). We concluded that PA-IVA offers a useful index to assess RVOT function in TOF patients. J. Med. Invest. 67 : 145-150, February, 2020.
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Ono et al. (2020) conducted an observational in Surgically repaired tetralogy of Fallot (n=79). Surgically repaired tetralogy of Fallot vs. Healthy controls was evaluated on Pulmonary annulus isovolumic acceleration (PA-IVA) (p=<0.05). Isovolumic acceleration of the pulmonary annulus was significantly lower in patients with surgically repaired tetralogy of Fallot compared to healthy controls (1.0 vs 2.4 m/s2, p<0.05).
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