What question did this study set out to answer?

To determine whether the reduction in pituitary growth hormone secretion during late pregnancy correlates quantitatively with gestational age throughout pregnancy.

July 1, 1970The Journal of Clinical Endocrinology & Metabolism

Impairment of Growth Hormone Secretion in Response to Hypoglycemia During Early and Late Pregnancy

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Authors

SYS. S. C. YENUniversity of California, San Diego PVPatricio A. VelaGeorgia Institute of Technology CTC. C. TSAINagoya University

Discussion

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Implication

Longitudinal study demonstrates progressive blunting of growth hormone release to hypoglycemia across pregnancy trimesters, indicating gestational hormone inhibition.

Key Points

To determine whether the reduction in pituitary growth hormone secretion during late pregnancy correlates quantitatively with gestational age throughout pregnancy.
Conducted sequential insulin-induced hypoglycemia stimulation tests during each of the three trimesters of pregnancy and at 6–7 weeks postpartum.
Evaluated a cohort of 10 non-obese pregnant individuals who served as their own postpartum controls.
Growth hormone responsiveness to hypoglycemia diminished progressively across each trimester, becoming severely blunted during the third trimester compared to postpartum levels.
Normal, brisk growth hormone release in response to hypoglycemia fully recovered by 6–7 weeks postpartum.

Cite This Study

YEN et al. (1970) studied this question.

synapsesocial.com/papers/6aa1f9ba53a31ffc17d3ca62 https://doi.org/10.1210/jcem-31-1-29

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Implication

Longitudinal study demonstrates progressive blunting of growth hormone release to hypoglycemia across pregnancy trimesters, indicating gestational hormone inhibition.

Impairment of Growth Hormone Secretion in Response to Hypoglycemia During Early and Late Pregnancy

Discussion

Member takes

Implication

Key Points

Cite This Study

Impairment of Growth Hormone Secretion in Response to Hypoglycemia During Early and Late Pregnancy

Discussion

Member takes

Implication

Key Points

Cite This Study

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