What is the clinical evidence from this study?

Study design: Other. Population: 5-fluorouracil-induced intestinal mucositis (n=40). Intervention: Ellagic acid vs. 5-fluorouracil alone. Primary outcome: Histological score of intestinal lesions (p=<0.05).

November 1, 2023Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512)Open Access

Assessment of ellagic acid action in 5-fluorouracil induced intestinal mucositis

Q: What are the key findings of this study?

Pretreatment with 10 mg/kg ellagic acid significantly improved histopathological scores (0.6 vs 2.6, p<0.05) and oxidative stress markers compared to 5-fluorouracil alone in mice.

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Key result

Ellagic acid pretreatment reduces intestinal lesions by ~77% and improves oxidative stress in 5-fluorouracil-treated mice.

P<0.05
n=40

Why the study?

5-Fluorouracil chemotherapy causes intestinal mucositis and undesirable symptoms, prompting investigation into how ellagic acid acts to attenuate 5-FU-induced intestinal mucositis and diarrhea in mice.

Does ellagic acid prevent 5-fluorouracil-induced intestinal mucositis in mice?

Population

Mice with 5-fluorouracil-induced intestinal mucositis

Comparison

Ellagic acid (10mg/kg or 5mg/kg daily) vs 5-FU alone

Design

Animal experimental study

Authors

DADareen Mahmood AL-hoshary MZMunaf H. ZalzalaUniversity of Baghdad

Discussion

Member takes

Implication

Hypothesis-generating for ellagic acid in 5-FU mucositis; clinical translation requires prospective human trials.

Structured PICO

Does ellagic acid prevent 5-fluorouracil-induced intestinal mucositis in mice?

Population

40 Albino male mice weighing 25-42 grams were used to evaluate the mucoprotective effects of ellagic acid against 5-fluorouracil-induced intestinal mucositis.

Intervention

Ellagic acid 10 mg/kg or 5 mg/kg orally once daily for 10 days, with 5-fluorouracil 50 mg/kg intraperitoneally daily for 4 days starting on day 7

Comparator

Normal saline orally for 10 days with 5-fluorouracil 50 mg/kg intraperitoneally daily for 4 days starting on day 7 (positive control), and normal saline with DMSO (negative control)

Outcome

Levels of superoxide dismutase (SOD), malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-α), and histopathological scoring in duodenal tissuesurrogate

Main Result

Absolute Event Rate: 0.6% vs 2.6%

p-value: p=<0.05

Ellagic acid pretreatment significantly attenuates 5-fluorouracil-induced intestinal mucositis in mice by reducing oxidative stress and inflammation.

Limitations

Animal model which may not fully translate to human clinical outcomes
Small sample size per group

Cite This Study

AL-hoshary et al. (2023) studied 5-fluorouracil-induced intestinal mucositis (n=40). Ellagic acid vs. 5-fluorouracil alone was evaluated on Histological score of intestinal lesions (p=<0.05). Pretreatment with 10 mg/kg ellagic acid significantly improved histopathological scores (0.6 vs 2.6, p<0.05) and oxidative stress markers compared to 5-fluorouracil alone in mice.

synapsesocial.com/papers/6aa20006caa787d02646eab0 https://doi.org/10.31351/vol32isssuppl.pp33-41

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Assessment of ellagic acid action in 5-fluorouracil induced intestinal mucositis

Discussion

Member takes

Implication

Structured PICO

Main Result

Limitations

Cite This Study

Assessment of ellagic acid action in 5-fluorouracil induced intestinal mucositis

Discussion

Member takes

Implication

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Also Consider