Key result
Pediatric kidney transplant links to severe diastolic dysfunction and reduced max VO2 vs healthy controls.
Why the study?
Do pediatric renal transplant recipients have impaired exercise capacity and cardiac function compared to healthy counterparts?
Cross-Sectional (n=44)
Do pediatric renal transplant recipients have impaired exercise capacity and cardiac function compared to healthy counterparts?
p-value: p=< 0.05
Pediatric renal transplant recipients exhibit significantly reduced exercise capacity and severe diastolic dysfunction compared to healthy children, highlighting their increased cardiovascular risk.
Supports closer CV monitoring in pediatric kidney transplant recipients; leaves open causal mechanisms and intervention targets.
Pediatric kidney transplant recipients are at increased risk of CVD. Exercise test is a good method to evaluate exercise capacity, cardiorespiratory fitness, and risk of potential CVDs. The aim of this study was to assess the exercise capacity in this population and determine its relationship with their cardiac function using conventional and tissue Doppler echocardiography. Exercise test, conventional and tissue Doppler echocardiography were performed on 44 kidney transplant children (age ranging 11-20, 59% male) with acceptable renal function, and the results were compared with their normal healthy counterparts. Our transplant patients achieved significantly lower maximal heart rate, maximal heart rate ratio, total energy expenditure during the exercise, and maximal O2 consumption (Max VO2 ) than the normal group (p < 0.05). No correlation was found between hemoglobin (Hb) level, dialysis duration, kidney function, and the exercise test parameters. Kidney transplant patients had preserved systolic despite diminished diastolic cardiac function compared to the normal children. Our pediatric renal transplant recipients had severely impaired diastolic dysfunction and significantly reduced MaxVO2 compared with their healthy counterparts. No correlation was found between MaxVO2 and measured indices of systolic and diastolic cardiac function.
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Derakhshan et al. (2014) conducted a cross-sectional in Pediatric kidney transplant (n=44). Kidney transplant recipient status vs. Normal healthy counterparts was evaluated on Maximal O2 consumption (Max VO2) and cardiac function (p=< 0.05). Pediatric kidney transplant recipients had severely impaired diastolic function and significantly reduced maximal O2 consumption compared with healthy counterparts (p < 0.05).
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