Key result
ECGs in childhood spinal muscular atrophy reveal a muscle tremor artifact in 100% of cases.
Why the study?
Does ECG show a specific artifact in patients with childhood spinal muscular atrophy?
Does ECG show a specific artifact in patients with childhood spinal muscular atrophy?
A "muscle tremor" artifact on ECG may serve as a consistent diagnostic clue for childhood spinal muscular atrophy.
May indicate a diagnostic clue in childhood spinal muscular atrophy; leaves open validation before any clinical adoption.
The appearance of tremors in patients with childhood, chronic spinal muscular atrophy has been known for years. We were struck by the presence of a "muscle tremor" artifact in the ECGs of all our patients with this diagnosis. This observation has not been noted previously. The consistency of this finding in patients with this disease is the basis for this report.
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Russman et al. (1979) studied this question. Electrocardiograms of patients with childhood spinal muscular atrophy consistently demonstrate a "muscle tremor" artifact in all cases.
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