IN recent years there has been increasing suspicion that prolonged or excessive use of analgesics may result in progressive renal damage very similar to that produced by chronic pyelonephritis. Phenacetin (acetophenetidin) has been widely incriminated as the offending drug, mainly because it was common to all the analgesic mixtures mentioned in the early reports. Histologically and functionally the renal lesions are predominantly tubular, with interstitial fibrosis, tubular degeneration and atrophy and a high incidence of papillary necrosis and pyelonephritis (Rubenstein, Abrahams, Stables & Levin, 1964).
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L. F. Prescott (1966) studied this question.
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