Key result
Single 1 mg parenteral vitamin B12 maintains pernicious anemia remission for up to 358 days.
Why the study?
Does a single parenteral dose of 1 mg of vitamin B12 prevent relapse in patients with untreated pernicious anaemia?
Population
15 patients with untreated pernicious anaemia
Design
Case_series
Follow-up
Up to 358 days
Authors
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May support extended B12 dosing intervals in uncomplicated pernicious anaemia; leaves open neurological safety and optimal schedules pending controlled trials.
Does a single parenteral dose of 1 mg of vitamin B12 prevent relapse in patients with untreated pernicious anaemia?
A single 1 mg parenteral dose of vitamin B12 can delay relapse in pernicious anemia for several months, but routine use at long intervals is not justified without further trials due to the risk of neurological deterioration.
Davies et al. (1952) studied untreated pernicious anaemia (n=15). vitamin B12 was evaluated on relapse. A single 1 mg parenteral dose of vitamin B12 maintained normal clinical and blood states for up to 358 days in pernicious anaemia, with the earliest relapse at 128 days.
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