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September 16, 2025SAGE Open Medical Case ReportsOpen Access

Masked vitamin B12 deficiency in pernicious anaemia: A diagnostic trap due to assay interference—Case report

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Authors

MAMohammed AbdulgayoomNational Center for Cancer Care and Research EAElabbass AbdelmahmuodHamad Medical Corporation AAAbdulrahman Al‐MashdaliNational Center for Cancer Care and Research

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Implication

Case report reveals elevated vitamin B12 levels caused by assay interference in a patient with pernicious anaemia, highlighting diagnostic challenges.

Key Points

Masked B12 deficiency can lead to diagnostic challenges in megaloblastic anaemia cases, complicating treatment.
A 64-year-old woman showed paradoxically elevated B12 levels yet suffered from macrocytic anaemia and pancytopaenia.
Positive anti-intrinsic factor antibodies caused assay interference, leading to falsely high serum B12 readings.
Prompt parenteral B12 therapy facilitated rapid recovery, underscoring the need for careful diagnostic evaluation.

Cite This Study

Abdulgayoom et al. (2025) studied this question.

synapsesocial.com/papers/68d4507331b076d99fa579df https://doi.org/10.1177/2050313x251377211

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Implication

Case report reveals elevated vitamin B12 levels caused by assay interference in a patient with pernicious anaemia, highlighting diagnostic challenges.

Masked vitamin B12 deficiency in pernicious anaemia: A diagnostic trap due to assay interference—Case report

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Implication

Key Points

Cite This Study

Masked vitamin B12 deficiency in pernicious anaemia: A diagnostic trap due to assay interference—Case report

Discussion

Member takes

Implication

Key Points

Cite This Study

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