Key result
Sleep-related amplification of cerebral flow oscillation is linked to lower total and subcortical WMH volumes.
Why the study?
Impaired sleep-related activation of the cerebral waste-clearance system may relate to brain aging, prompting investigation into whether sleep-associated cerebral blood-flow pattern changes reflect this activation and associate with white-matter hyperintensity volume.
Does the periodicity of cerebral blood flow velocity during sleep associate with white-matter hyperintensity volume in healthy volunteers?
Cross-Sectional (n=50)
No
Does the periodicity of cerebral blood flow velocity during sleep associate with white-matter hyperintensity volume in healthy volunteers?
Sleep-related amplification of cerebral flow-velocity periodicity is inversely associated with white-matter hyperintensity volume, suggesting a link between sleep-activated cerebral waste clearance and brain aging.
Hypothesis-generating for sleep flow oscillations mitigating white-matter injury; prospective studies needed before any clinical application.
Impaired sleep-related activation of the cerebral waste-clearance system might be related with the brain aging process. We hypothesized that cerebral blood-flow pattern changes during sleep might reflect the activation of the cerebral waste-clearance system and investigated its association with the cerebral white-matter hyperintensity (WMH) volume. Fifty healthy volunteers were prospectively recruited. In addition to the baseline transcranial Doppler parameters, the mean flow velocity (MFV) of the middle cerebral artery was monitored during waking and short-term non-REM sleep. Spectral density analysis was performed to analyze the periodic MFV variation patterns. For the aged subgroup (>50 years, n = 25), the WMH volumes in the total, subcortical, and periventricular regions were measured. The MFV periodic pattern during sleep was substantially augmented over that in the waking status. Spectral density analysis of MFV showed a noticeable peak in the very-low-frequency (VLF) band during sleep status (sleep/waking ratio 2.87 ± 2.71, P < 0.001). In linear regression analysis in the aged subgroup, the sleep/waking ratio of the VLF peak was inversely associated with total (P = 0.013) and subcortical (P = 0.020) WMH volumes. Sleep-related amplification of the cerebral flow-velocity periodicity might reflect the activation of cerebral waste clearance system during sleep, and be related to the pathogenesis of cerebral WMH.
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Lee et al. (2019) conducted a cross-sectional in Healthy volunteers (n=50). Short-term non-REM sleep vs. Waking status was evaluated on Total white-matter hyperintensity (WMH) volume (B coefficient -0.517, 95% CI -0.915 to -0.120, p=0.013). Sleep-related amplification of cerebral flow oscillation, measured as the sleep/waking ratio of very-low-frequency peak power, was inversely associated with total and subcortical white-matter hyperintensity volumes.
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