Key result
Prophylactic antibiotics within one hour of incision linked to ~84% fewer SSIs versus delayed administration.
Why the study?
Does timely administration of prophylactic antibiotics within 1 hour of incision reduce surgical site infections in patients undergoing elective colorectal surgery?
Observational (n=104)
Does timely administration of prophylactic antibiotics within 1 hour of incision reduce surgical site infections in patients undergoing elective colorectal surgery?
Absolute Event Rate: 3.5% vs 22%
p-value: p=0.005
Timely administration of prophylactic antibiotics within 1 hour of incision significantly reduces the incidence of surgical site infections in elective colorectal surgery.
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May support timely antibiotics in elective colorectal surgery; leaves open need for randomized confirmation.
Nguyen et al. (2008) conducted an observational in Elective colorectal surgery (n=104). Prophylactic antibiotics administered within 1 hour of incision vs. Prophylactic antibiotics not administered within 1 hour of incision was evaluated on Surgical site infection (SSI) (p=0.005). Administration of prophylactic antibiotics within 1 hour of incision significantly reduced surgical site infections compared to delayed administration (3.5% vs 22%, P=0.005).
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