Key result
Adenoviral AC-VI gene transfer creates a biological pacemaker in 100% of treated pigs.
Why the study?
Does adenoviral gene transfer of AC-VI create biological pacemaker activity in a porcine AV node block model?
Does adenoviral gene transfer of AC-VI create biological pacemaker activity in a porcine AV node block model?
Absolute Event Rate: 100% vs 0%
Adenoviral gene transfer of Adenylate-Cyclase type VI successfully created a biological pacemaker system in a porcine AV node block model.
AC-VI gene transfer creates biological pacemakers in pigs; leaves open translation to human AV block.
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Ruhparwar et al. (2010) studied AV node block (n=9). Adenoviral gene transfer of Adenylate-Cyclase type VI (AC-VI) vs. Beta-Galactosidase (lacZ) gene was evaluated on Escape rhythm originating from the left ventricular injection site. Adenoviral gene transfer of Adenylate-Cyclase type VI created a biological pacemaker with an escape rhythm of 100 beats/min originating from the injection site in 100% of treated pigs.
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