August 22, 2006Circulation
Bioartificial Sinus Node Constructed via In Vivo Gene Transfer of an Engineered Pacemaker HCN Channel Reduces the Dependence on Electronic Pacemaker in a Sick-Sinus Syndrome Model
Why the study?
Does in vivo gene transfer of an engineered pacemaker HCN channel reduce the dependence on electronic pacemakers in a sick-sinus syndrome model?
Population
Guinea pig hearts and a porcine model of sick-sinus syndrome generated by guided radiofrequency ablation of…
Design
Preclinical
Authors
Discussion
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Implication
May support biological pacing development; hypothesis-generating and should not yet change clinical practice.
Structured PICO
Does in vivo gene transfer of an engineered pacemaker HCN channel reduce the dependence on electronic pacemakers in a sick-sinus syndrome model?
P
Population
Guinea pig hearts and a porcine model of sick-sinus syndrome generated by guided radiofrequency ablation of the native SA node, followed by implantation of a dual-chamber electronic pacemaker
I
Intervention
In situ focal expression of HCN1-DeltaDeltaDelta via recombinant adenovirus Ad-CMV-GFP-IRES-HCN1-DeltaDeltaDelta
O
Outcome
Impulse generation and conduction, automaticity, and reduction of electronic pacingsurrogate
In vivo gene transfer of an engineered HCN channel creates a functional bioartificial sinus node that can reliably pace the myocardium and reduce dependence on electronic pacemakers in a porcine model of sick-sinus syndrome.
Cite This Study
Tse et al. (2006) studied this question.