Key result
Vildagliptin beats metformin in preventing cardiac and mitochondrial dysfunction in insulin-resistant rats.
Why the study?
Does metformin or vildagliptin improve cardiac and mitochondrial function in rats with high-fat diet-induced insulin resistance?
Population
Male Wistar rats fed with either a normal diet or high-fat diet for 12 weeks to induce insulin resistance
Comparison
Metformin or vildagliptin for 21 days vs Vehicle
Design
Preclinical
Follow-up
21 days
Authors
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Rat findings do not support changing metformin use; leaves open whether vildagliptin confers superior cardiac protection in insulin-resistant patients.
Does metformin or vildagliptin improve cardiac and mitochondrial function in rats with high-fat diet-induced insulin resistance?
In a rat model of high-fat diet-induced insulin resistance, vildagliptin was more effective than metformin in preventing cardiac sympathovagal imbalance, cardiac dysfunction, and mitochondrial dysfunction.
Apaijai et al. (2012) studied Insulin resistance induced by high-fat diet (n=48). Vildagliptin and Metformin vs. Vehicle was evaluated on Heart rate variability (HRV), cardiac function, and cardiac mitochondrial function. Vildagliptin was more effective than metformin in preventing cardiac sympathovagal imbalance, cardiac dysfunction, and cardiac mitochondrial dysfunction in rats with insulin resistance.
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