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ABCD ring system of antitumor alkaloid camptothecin (1), basic framework of nothapodytine B (2), was prepared from 2-chloro-3-hydroxymethylquinoline (4) in 7 steps.The key reaction involves intramolecular hetero Diels-Alder reaction.
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Ihara et al. (2000) studied this question.
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