Key result
TAVR linked to ~93% higher midterm mortality versus miAVR but less AKI.
Why the study?
With TAVR approved for intermediate- and low-risk patients and renewed interest in miAVR, outcomes between TAVR and miAVR needed comparison.
Does transcatheter aortic valve replacement compared to minimally invasive aortic valve replacement improve clinical outcomes in patients with aortic stenosis?
Meta-Analysis
Does transcatheter aortic valve replacement compared to minimally invasive aortic valve replacement improve clinical outcomes in patients with aortic stenosis?
Relative Risk: 1.93 (95% CI 1.16–3.22)
In a meta-analysis of cohort studies, TAVR was associated with higher midterm mortality and paravalvular leakage but lower acute kidney injury and shorter hospital stay compared to minimally invasive surgical aortic valve replacement.
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May support minimally invasive surgery over TAVR to lower midterm mortality; leaves open confirmation in randomized trials.
Sayed et al. (2021) conducted a meta-analysis in Aortic stenosis. Transcatheter aortic valve replacement (TAVR) vs. Minimally invasive aortic valve replacement (miAVR) was evaluated on Midterm mortality (≥1 year) (RR 1.93, 95% CI 1.16 to 3.22). Transcatheter aortic valve replacement was associated with higher midterm mortality compared with minimally invasive surgery (RR 1.93; 95% CI 1.16-3.22), but lower acute kidney injury.
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