Key result
This review summarizes current evidence from randomized trials, registries, and guidelines on the early prescription of P2Y12 inhibitors prior to coronary angiography in patients with ACS.
Why the study?
Whether it is expedient to prescribe P2Y12 inhibitors early to patients with ACS prior to coronary angiography when coronary anatomy is unknown has been widely debated.
Does early prescription of platelet P2Y12 receptor inhibitors prior to coronary angiography provide benefit or harm in patients with acute coronary syndrome?
Does early prescription of platelet P2Y12 receptor inhibitors prior to coronary angiography provide benefit or harm in patients with acute coronary syndrome?
This review synthesizes current evidence on the controversial topic of early P2Y12 inhibitor administration prior to coronary angiography in patients with ACS.
Answers are grounded in this paper and cite their sources.
Highlights ongoing uncertainty in ACS; leaves open optimal pre-angiography P2Y12 timing for practice and trials.
Double antiplatelet therapy, which includes aspirin and platelet P2Y12 receptor inhibitors (hereinafter P2Y12 inhibitor) is the main component of treatment and secondary prevention after ACS. In recent years, the issue of determining whether it is expedient for P2Y12 inhibitors to be early prescribed to patients with ACS – prior to coronary angiography, when coronary anatomy is unknown – has been widely debated. The review provides comprehensive up-to-date information on this topic based on data from randomized trials, registers, and official clinical guidelines.
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Р. М. Шахнович (2018) conducted a review in Acute Coronary Syndrome (ACS). Early prescription of platelet P2Y12 receptor inhibitors was evaluated. This review summarizes current evidence from randomized trials, registries, and guidelines on the early prescription of P2Y12 inhibitors prior to coronary angiography in patients with ACS.
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