Key result
PPIs or H. pylori eradication may mitigate the increased age-related risk of aspirin-induced GI damage.
Understanding age-related gastrointestinal changes may help improve aspirin tolerability in older adults, potentially expanding its use for disease prevention.
May warrant gastroprotective strategies in older aspirin users; leaves open optimal interventions pending prospective trials.
Interventions to reduce mortality and disability in older people are vital. Aspirin is cheap and effective and known to prevent cardiovascular and cerebrovascular disease, many cancers, and Alzheimer dementia. The widespread use of aspirin in older people is limited by its gastrointestinal side effects. Understanding age-related changes in gastrointestinal physiology that could put older people at risk of the side effects of aspirin may direct strategies to improve tolerance and hence lead to greater numbers of older people being able to take this effective intervention.
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Julia L. Newton (2006) conducted a review in Gastrointestinal side effects of aspirin. Aspirin was evaluated. Age-related changes in gastrointestinal physiology increase susceptibility to aspirin-induced damage, and strategies like Helicobacter pylori eradication or proton pump inhibitors may improve tolerance.
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