Key result
Avocado leaf extract nanoparticles lower SBP by ~69 mmHg in salt-induced hypertensive rats.
Why the study?
Long-term chemical antihypertensive drugs can cause intolerable side effects, prompting interest in whether avocado leaf extract can effectively inhibit ACE, lower blood pressure, and increase urine volume compared to modern drugs.
Does avocado leaf extract reduce blood pressure and increase urine volume in NaCl-induced hypertensive rats?
Does avocado leaf extract reduce blood pressure and increase urine volume in NaCl-induced hypertensive rats?
Mean Difference: 59.8
Absolute Event Rate: 105.8% vs 165.7%
p-value: p=0.004
Avocado leaf extract demonstrated significant antihypertensive effects in a rat model, reducing both systolic and diastolic blood pressure while inhibiting the ACE enzyme.
No immediate clinical implications; leaves open translation of avocado leaf nanoparticles to human hypertension trials.
Background Long-term chemical drug consumption to treat hypertension may have side effects because the levels are sometimes difficult for the body to tolerate. Therefore, some people have used plants as herbal medicine, including avocado leaves ( Persea americana Mill.) as antihypertensive. This study aims to find out the differences in the effectiveness of modern drugs and natural antihypertensive ingredients in avocado leaf extract (containing flavonoids and quercetin compounds) in inhibiting the ACE enzyme, which causes decreasing systolic blood pressure (SBP) and diastolic blood pressure (DBP) as well as increasing urine volume. Methods This study used an experimental in vivo study design involving 24 white male Wistar rats ( Rattus norvegicus ), aged 2–3 months, weighing 130–250 g, and of a healthy condition with active movement. The samples were randomly divided into six treatment groups and post-test only research design with control group design. Results The result of the study showed that avocado leaf extract was effective in reducing blood pressure in Wistar rats with hypertension induced by 16% NaCl for 14 days. SBP fell from 164.92 mmHg to 116.83 mmHg and DBP from 118.42 mmHg to 82.83 mmHg. One-way ANOVA test value significance SBP p=0.000 and Kruskal–Wallis test value of DBP p=0.030, Kruskal–Wallis test urine volume value of p=0.002. The statistical test results proved that avocado leaf extract significantly reduced the blood pressure and increased the urine volume in hypertensive rats. The ACE inhibitor test, performed using an ELISA, showed that the extract inhibition against the ACE enzyme was 60.0±12.1%, serum nitrate levels 41.1±11.5. The decrease in blood pressure occurred because the extract contained a quercetin compound discovered by the high-performance liquid chromatography (HPLC) method of 1129.597 ppm. Conclusions The study showed that the leaf extract of Persea americana Mill. was effective as an antihypertensive.
No takes yet. Share an insight, caveat, or question.
Sutiningsih et al. (2022) studied Hypertension (n=24). Avocado leaf extract (Persea americana Mill.) and nanoparticles vs. 16% NaCl (negative control) was evaluated on Systolic blood pressure (SBP) at day 22 (Mean difference 59.8 mmHg, p=0.004). Avocado leaf extract nanoparticles significantly reduced systolic blood pressure by 68.75 mmHg in salt-induced hypertensive Wistar rats compared to baseline.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: