Key result
Evolutionary analysis reveals myosin surface loops are more constrained than the rest of the molecule.
Population
Myosin molecules
Comparison
Analysis of relative rates of observed… vs Sequences of the rest of the myosin molecule
Design
Preclinical
Authors
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Hypothesis-generating for myosin isoform kinetics in muscle; leaves open cardiac disease relevance pending mammalian validation.
Evolutionary analysis suggests that surface loops of myosin are highly constrained among kinetically similar isoforms, indicating their importance in determining functional characteristics.
Goodson et al. (1999) studied Myosin structure-function. Myosin loop regions vs. Rest of the myosin molecule was evaluated on Relative rates of observed evolutionary change. Evolutionary analysis of myosin sequences showed that surface loop regions are more constrained than the rest of the molecule when comparing kinetically or developmentally similar myosins.
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